Since version 14 communication between Password Depot and the add on can be protected with a separate password additionally.
This way, you can avoid malware which may be on your computer knowing the data format of Password Depot to specifically send requests to Password Depot in order to try this way to get access to your personal data and passwords.
This hypothetical attack can thus be avoided with an additional password, too and it is not necessary to further explain here why you have to make sure that your computer is free from computer viruses or any other malware.
If you don't want to use an additional password for the add on you can deactivate this specific feature in Options -> Browsers -> Protect access with a password:
HINT: External dangerous websites will never be able to try to get access to your data because Password Depot has always been permitting local requests through 127.0.0.1 only.